Mass Transfer Modulation and Gas Mapping Based on Covalent Organic Frameworks-covered Theta Micropipette.

Covalent natural frameworks (COFs) consist nanochannels which are basically essential for his or her utility. Up to now, the impact of gasoline section on COF nanochannels are exhausting to discover. Here, TAPB-PDA-COFs (triphenylbenzene-terephthaldehyde-COFs) was synthesized in-situ on the tip of a theta micropipette. The COF-covered theta micropipette (CTP) create a steady gas-liquid interface contained in the COF na-nochannels, by means of which the humidity-modulated ion mass switch within the COF nanochannels will be recorded by recording the present throughout the 2 channels of the theta micropipette.

Results present that the humid air adjustments the mobility of the ions contained in the COF nanochannels, which ends up in the change of ionic present. Humid air confirmed completely different results on the ion switch relying on the solvent polarity index and vapor stress. Current decreases linearly with the rise of relative humidity (RH) from 11% to 98%. The CTP was additionally mounted on the scanning electrochemical microscopy as a probe electrode for mapping micrometer-scale humidity distribution.

Preclinical validation of the micropipette-guided drug administration (MDA) methodology within the maternal immune activation mannequin of neurodevelopmental problems.

Pharmacological remedies in laboratory rodents stay a cornerstone of preclinical psychopharmacological analysis and drug growth. There are quite a few methods through which acute or persistent pharmacological remedies will be applied, with every methodology having sure benefits and drawbacks.

Here, we describe and validate a novel therapy methodology in mice, which we consult with because the micropipette-guided drug administration (MDA) process. This administration methodology relies on a sweetened condensed milk answer as a automobile for pharmacological substances, which motivates the animals to eat automobile and/or drug options voluntarily within the presence of the experimenter.

In a proof-of-concept research, we present that the pharmacokinetic profiles of the atypical antipsychotic drug, risperidone, have been related whether or not administered by way of the MDA process or by way of the standard oral gavage methodology. Unlike the latter, nevertheless, MDA didn’t induce the stress hormone, corticosterone. Furthermore, we assessed the suitability and validity of the MDA methodology in a mouse mannequin of maternal immune activation, which is incessantly used as a mannequin of immune-mediated neurodevelopmental problems.

Mass Transfer Modulation and Gas Mapping Based on Covalent Organic Frameworks-covered Theta Micropipette.

Using this mannequin, we discovered that persistent therapy (> Four weeks, as soon as per day) with risperidone by way of MDA led to a dose-dependent mitigation of MIA-induced social interplay deficits and amphetamine hypersensitivity. Taken collectively, the MDA process described herein represents a novel pharmacological administration methodology for per os remedies in mice that’s simple to implement, price efficient, non-invasive, and much less irritating for the animals than typical oral gavage strategies.

On-chip floor acoustic wave and micropipette aspiration strategies to evaluate cell elastic properties.

The cytoskeletal mechanics and cell mechanical properties play an essential position in mobile behaviors. In this research, as a way to present complete insights into the connection between completely different cytoskeletal elements and mobile elastic moduli, we constructed a phase-modulated floor acoustic wave microfluidic machine to measure mobile compressibility and a microfluidic micropipette-aspiration machine to measure mobile Young’s modulus. The microfluidic gadgets have been validated primarily based on experimental information and computational simulations.

The contributions of structural cytoskeletal actin filament and microtubule to mobile compressibility and Young’s modulus have been examined in MCF-7 cells. The compressibility of MCF-7 cells was elevated after microtubule disruption, whereas actin disruption had no impact. In distinction, Young’s modulus of MCF-7 cells was diminished after actin disruption however unaffected by microtubule disruption. The actin filaments and microtubules have been stained to verify the structural alteration in cytoskeleton.

Our findings counsel the dissimilarity within the structural roles of actin filaments and microtubules when it comes to mobile compressibility and Young’s modulus. Based on the variations in location and construction, actin filaments primarily contribute to tensile Young’s modulus and microtubules primarily contribute to compressibility. In addition, completely different responses to cytoskeletal alterations between acoustophoresis and micropipette aspiration demonstrated that micropipette aspiration was higher at detecting the change from actin cortex, whereas the response to acoustophoresis was ruled by microtubule networks.

Development of an automatic micropipette coating methodology for drug-coated balloons.

Drug-coated balloons (DCBs) are a current know-how developed to deal with peripheral artery illness (PAD). Along with an appropriate formulation of antiproliferative drug and excipient, coating methodology is a vital side of a DCB as these components have an effect on coating traits and drug supply to the therapy web site.

The a number of launch tailor-made medical gadgets DCB (MR-TMD-DCB), designed to realize a number of inflations to deal with complicated PAD, accommodates paclitaxel (PAT) because the antiproliferative drug and polyethylene oxide (PEO) because the excipient. In our earlier research, the MR-TMD-DCB was coated utilizing a handbook dip coating methodology.

In this research, an automatic micropipette coating methodology was developed utilizing a modified spray coating instrument to coat the MR-TMD-DCB. First, the coating formulation and technique was optimized. A drug formulation of 16 wt% PAT and 4% wt/vol PEO, a polymer formulation of two.5% wt/vol PEO, and a complete of two drug layers produced a largely uniform and skinny coating with no defects and acceptable drug load.

The balloon additionally had optimum drug uptake in arterial tissue in an in vitro circulation mannequin. Next, the reproducibility of the coating technique was improved by optimizing the instrument parameters.

Fixvo II Micropipette - 500 Capacity -

LA607-1NO 1 unit
EUR 34.73
Description: Fixvo II Micropipette - 500 Capacity -

Varivol II Micropipette-1000 Capacity

LA614-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-1000 Capacity

Varivol II Micropipette-1000 Capacity

LA616-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-1000 Capacity

Varivol II Micropipette-5000 Capacity

LA619-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-5000 Capacity

Varivol II Micropipette-200 Capacity :

LA613-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-200 Capacity :

Varivol II Micropipette-100 Capacity :

LA615-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-100 Capacity :

Varivol II Micropipette-200 Capacity :

LA618-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-200 Capacity :

Varivol II Micropipette-10000 Capacity :

LA878-1NO 1 unit
EUR 75.54
Description: Varivol II Micropipette-10000 Capacity :

Varivol II Micropipette-10 Capacity :

LA611-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-10 Capacity :

Varivol II Micropipette-50 Capacity :

LA612-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-50 Capacity :

Varivol II Micropipette-20 Capacity :

LA617-1NO 1 unit
EUR 61.99
Description: Varivol II Micropipette-20 Capacity :

Fixvo II Micropipette - 5 Capacity - 5

LA599-1NO 1 unit
EUR 34.73
Description: Fixvo II Micropipette - 5 Capacity - 5

Fixvo II Micropipette - 10 Capacity -

LA600-1NO 1 unit
EUR 34.73
Description: Fixvo II Micropipette - 10 Capacity -

Micropipette Acura 825 0.1-2 uL Socorex - EACH

DD61104 EACH
EUR 488.7

Micropipette Acura 825 2-20 uL Socorex - EACH

DD61107 EACH
EUR 450.9

Micropipette Acura 825 20-200 uL Socorex - EACH

DD61110 EACH
EUR 450.9

Micropipette Acura 825 100-1000 uL Socorex - EACH

DD61111 EACH
EUR 450.9

Micropipette Acura 835 1-10 uL Socorex - EACH

DD61113 EACH
EUR 487.35

Pe Filter For Micropipette Protection - PK100

DD061968 PK100
EUR 152.55

µPet Autoclavable Micropipette Capacity:

LA955-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA956-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA957-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA958-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA959-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA960-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA961-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA962-1NO 1 unit
EUR 145.85
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette Capacity:

LA963-1NO 1 unit
EUR 84.57
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette 8-channel

LA964-1NO 1 unit
EUR 601.15
Description: µPet Autoclavable Micropipette 8-channel

µPet Autoclavable Micropipette 8-channel

LA965-1NO 1 unit
EUR 601.15
Description: µPet Autoclavable Micropipette 8-channel

µPet Autoclavable Micropipette Capacity:

LA966-1NO 1 unit
EUR 601.15
Description: µPet Autoclavable Micropipette Capacity:

µPet Autoclavable Micropipette 8-channel

LA967-1NO 1 unit
EUR 601.15
Description: µPet Autoclavable Micropipette 8-channel

Capillary micropipette Microcaps Drummond 0.5ulger) for pipettes 1 to 100 mL - PK100

DD075071 PK100
EUR 49.95

Positive displacement micropipette Acura capillar 846 volume 1 - 2 - 4 - 5 uL - EACH

DD61945 EACH
EUR 537.3

Positive displacement micropipette Acura capillar 846 volume 10 - 20 - 30 - 40 - 50 uL - EACH

DD61947 EACH
EUR 537.3

Positive displacement micropipette Acura capillar 846 volume 60 - 75 - 80 - 90 - 100 uL - EACH

DD61948 EACH
EUR 537.3

Microscope Cover Glass

BG011C-10X100NO 1 unit
EUR 44.42
Description: Microscope Cover Glass

Microscope Cover Glass

BG011C-5X100NO 1 unit
EUR 23.46
Description: Microscope Cover Glass

Microscope Cover Glass

BG012C-5X100NO 1 unit
EUR 31.97
Description: Microscope Cover Glass

Microscope Cover Glass

BG013C-10X100NO 1 unit
EUR 65.86
Description: Microscope Cover Glass

Microscope Cover Glass

BG013C-5X100NO 1 unit
EUR 34.89
Description: Microscope Cover Glass

Microscope Cover Glass

BG014C-10X100NO 1 unit
EUR 106.84
Description: Microscope Cover Glass

Microscope Cover Glass

BG014C-5X100NO 1 unit
EUR 56.25
Description: Microscope Cover Glass

Microscope Cover Glass

BG015C-10X100NO 1 unit
EUR 72.85
Description: Microscope Cover Glass

Microscope Cover Glass

BG015C-5X100NO 1 unit
EUR 38.44
Description: Microscope Cover Glass

Filter Syringe Glass Microfibre - PK500

68061316 PK500
EUR 1223.1

WHATMAN(TM) GLASS MICROFIBER FILTRATION

WHA1950009 EACH
EUR 282.15

WHATMAN(TM) GLASS MICROFIBER FILTRATION

WHA1950017 EACH
EUR 280.17

WHATMAN(TM) GLASS MICROFIBER FILTRATION

WHA1950217 EACH
EUR 156.42

WHATMAN(TM) GLASS MICROFIBER FILTERS GR

WHA18226580 EACH
EUR 144.54

WHATMAN(TM) GLASS MICROFIBER FILTERS GR

WHA1822866 EACH
EUR 293.04

WHATMAN(TM) GLASS MICROFIBER FILTERS GR

WHA1823007 EACH
EUR 108.9

WHATMAN(TM) GLASS MICROFIBER FILTERS GR

WHA1823915 EACH
EUR 1101.87

WHATMAN(TM) GLASS MICROFIBER FILTERS GR

WHA1825015 EACH
EUR 196.02

WHATMAN(TM) GLASS MICROFIBER FILTERS GR

WHA1825037 EACH
EUR 111.63

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1820025 EACH
EUR 26.58

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1821021 EACH
EUR 25.74

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1821024 EACH
EUR 47.52

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1821025 PK100
EUR 51.48

WHATMAN GLASS MICROFIBER FILTER DIAM. 4

WHA1821042 PK100
EUR 72.27

WHATMAN GLASS MICROFIBER FILTER DIAM. 4

WHA1821047 EACH
EUR 79.2

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1821150 EACH
EUR 96.03

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1822021 PK100
EUR 48.51

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1822024 EACH
EUR 45.54

WHATMAN GLASS MICROFIBER FILTER DIAM. 3

WHA1822037 EACH
EUR 51.48

WHATMAN GLASS MICROFIBER FILTER DIAM. 4

WHA1822042 EACH
EUR 51.48

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1822110 EACH
EUR 164.34

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1822150 EACH
EUR 361.35

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1823021 PK100
EUR 36.63

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1823024 EACH
EUR 31.68

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1823025 EACH
EUR 39.6

WHATMAN GLASS MICROFIBER FILTER DIAM. 4

WHA1823042 EACH
EUR 45.54

WHATMAN GLASS MICROFIBER FILTER DIAM. 7

WHA1823070 PK100
EUR 94.05

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1823110 EACH
EUR 40.59

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1823125 EACH
EUR 59.4

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1823150 EACH
EUR 101.97

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1825021 EACH
EUR 66.33

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1825024 EACH
EUR 88.11

WHATMAN GLASS MICROFIBER FILTER DIAM. 2

WHA1825025 EACH
EUR 85.8

WHATMAN GLASS MICROFIBER FILTER DIAM. 4

WHA1825042 EACH
EUR 122.76

WHATMAN GLASS MICROFIBER FILTER DIAM. 7

WHA1825070 EACH
EUR 199.95

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1825125 PK25
EUR 145.53

WHATMAN GLASS MICROFIBER FILTER DIAM. 1

WHA1825150 EACH
EUR 189.09

WHATMAN GF/F 25.7CM DIAM GLASS MICROFIB

WHA1825257 EACH
EUR 418.38

WHATMAN(TM) GLASS MICROFIBER FILTRATION - EACH

WHA1950002 EACH
EUR 261.9

WHATMAN STANDARD GLASS MICROFIBER EXTRAC - PK25

WHA10371025 PK25
EUR 280.8

WHATMAN STANDARD GLASS MICROFIBER EXTRAC - EACH

WHA10371042 EACH
EUR 248.4

WHATMAN(TM) GLASS MICROFIBER FILTERS GR - EACH

WHA1821914 EACH
EUR 396.9

WHATMAN(TM) GLASS MICROFIBER FILTERS GR - PK25

WHA1825293 PK25
EUR 756

WHATMAN GF/D 25.7CM DIAM GLASS MICROFI - EACH

WHA1823257 EACH
EUR 164.7

WHATMAN(TM) GLASS MICROFIBER FILTERS WI - PK200

WHA10421030 PK200
EUR 171.45

WHATMAN GLASS MICROFIBER FILTER DIAM. 2 - EACH

WHA1820024 EACH
EUR 43.2

WHATMAN GLASS MICROFIBER FILTER DIAM. 4 - EACH

WHA1820042 EACH
EUR 49.95

WHATMAN(TM) GLASS MICROFIBER FILTERS GR - PK100

WHA1820240 PK100
EUR 278.1

WHATMAN GLASS MICROFIBER FILTER DIAM. 3 - EACH

WHA1821037 EACH
EUR 87.75

WHATMAN GLASS MICROFIBER FILTER DIAM. 1 - EACH

WHA1821110 EACH
EUR 59.4

WHATMAN GLASS MICROFIBER FILTER DIAM. 5 - EACH

WHA1823055 EACH
EUR 81

WHATMAN GLASS MICROFIBER FILTER DIAM. 9 - EACH

WHA1823090 EACH
EUR 41.85

WHATMAN GLASS MICROFIBER FILTER DIAM. 1 - PK25

WHA1825110 PK25
EUR 163.35

WHATMAN (R) GLASS MICROFIBER MEMBRANE HO - EACH

WHA1960054 EACH
EUR 691.2

WHATMAN GLASS MICROFIBER FILTER DIAM. 2 - PK100

WHA1820021 PK100
EUR 47.25

WHATMAN GLASS MICROFIBER FILTER DIAM. 4 - PK100

WHA1820047 PK100
EUR 74.91

WHATMAN GLASS MICROFIBER FILTER DIAM. 7 - PK100

WHA1821070 PK100
EUR 216

WHATMAN GLASS MICROFIBER FILTER DIAM. 5 - PK100

WHA1825055 PK100
EUR 271.35

WHATMAN(R) GLASS MICROFIBER FILTERS GRA - PK100

WHA1827025 PK100
EUR 32.4

Whatman GFB 90mm Membrane Glass Microfibre - PK25

FIL4218 PK25
EUR 54

Whatman GFB 110mm Membrane Glass Microfibre - PK25

FIL4220 PK25
EUR 63.45

Whatman GFB 125mm Membrane Glass Microfibre - PK25

FIL4222 PK25
EUR 82.35

Whatman GFB 150mm Membrane Glass Microfibre - PK25

FIL4226 PK25
EUR 125.55

Whatman GFB 185mm Membrane Glass Microfibre - PK25

FIL4228 PK25
EUR 157.95

Whatman GFD 90mm Membrane Glass Microfibre - PK25

FIL4420 PK25
EUR 44.55

Whatman GFD 110mm Membrane Glass Microfibre - PK25

FIL4422 PK25
EUR 59.4

Whatman GFD 125mm Membrane Glass Microfibre - PK25

FIL4424 PK25
EUR 76.95

Whatman GFD 150mm Membrane Glass Microfibre - PK25

FIL4426 PK25
EUR 132.3

Whatman GFF 90mm Membrane Glass Microfibre - PK25

FIL4516 PK25
EUR 91.8

Whatman GFF 110mm Membrane Glass Microfibre - PK25

FIL4518 PK25
EUR 125.55

Whatman GFF 125mm Membrane Glass Microfibre - PK25

FIL4520 PK25
EUR 152.55

Whatman GFF 150mm Membrane Glass Microfibre - PK25

FIL4522 PK25
EUR 222.75

Whatman GFA 55mm Membrane Glass Microfibre - BX100

FIL4116 BX100
EUR 59.4

Whatman GFA 70mm Membrane Glass Microfibre - PK100

FIL4120 PK100
EUR 74.25

Whatman GFA 90mm Membrane Glass Microfibre - PK100

FIL4122 PK100
EUR 105.3

Whatman GFA 125mm Membrane Glass Microfibre - PK100

FIL4126 PK100
EUR 174.15

Whatman GFA 150mm Membrane Glass Microfibre - PK100

FIL4128 PK100
EUR 211.95

Whatman GFB 25mm Membrane Glass Microfibre - PK100

FIL4204 PK100
EUR 66.15

Whatman GFB 47mm Membrane Glass Microfibre - PK100

FIL4210 PK100
EUR 103.95

Whatman GFB 70mm Membrane Glass Microfibre - PK100

FIL4216 PK100
EUR 163.35

Whatman GFC 47mm Membrane Glass Microfibre - PK100

FIL4310 PK100
EUR 83.7

Whatman GFC 55mm Membrane Glass Microfibre - PK100

FIL4312 PK100
EUR 98.55

Whatman GFC 70mm Membrane Glass Microfibre - PK100

FIL4314 PK100
EUR 116.1

Whatman GFC 90mm Membrane Glass Microfibre - PK100

FIL4316 PK100
EUR 157.95

Whatman GFC 110mm Membrane Glass Microfibre - PK100

FIL4318 PK100
EUR 213.3

Whatman GFC 125mm Membrane Glass Microfibre - PK100

FIL4320 PK100
EUR 257.85

Whatman GFC 150mm Membrane Glass Microfibre - PK100

FIL4322 PK100
EUR 467.1

Whatman GFD 25mm Membrane Glass Microfibre - PK100

FIL4408 PK100
EUR 51.3

Whatman GFD 47mm Membrane Glass Microfibre - PK100

FIL4414 PK100
EUR 75.6

Whatman GFD 70mm Membrane Glass Microfibre - PK100

FIL4418 PK100
EUR 118.8

Whatman GFF 25mm Membrane Glass Microfibre - PK100

FIL4504 PK100
EUR 117.45

Whatman GFF 47mm Membrane Glass Microfibre - PK100

FIL4510 PK100
EUR 182.25

Whatman GFF 55mm Membrane Glass Microfibre - PK100

FIL4512 PK100
EUR 207.9

Whatman GFF 70mm Membrane Glass Microfibre - PK100

FIL4514 PK100
EUR 247.05

Glass Microfibre Filter Discs Gr SS - 25mm - PK100

SLS4530 PK100
EUR 32.4

Glass Microfibre Filter Discs Gr SS - 47mm - PK100

SLS4531 PK100
EUR 39.15

Glass Microfibre Filter Discs Gr SS - 55mm - PK100

SLS4532 PK100
EUR 51.3

Glass Microfibre Filter Discs Gr SS - 70mm - PK100

SLS4533 PK100
EUR 63.45

Glass Microfibre Filter Discs Gr SS - 90mm - PK100

SLS4534 PK100
EUR 90.45

Glass Microfibre Filter Discs Gr SS - 110mm - PK100

SLS4535 PK100
EUR 113.4

Glass Microfibre Filter Discs Gr SS - 125mm - PK100

SLS4536 PK100
EUR 170.1

Glass Microfibre Filter Discs Gr SS - 150mm - PK100

SLS4537 PK100
EUR 211.95

Sartorius MGC 150mm Membrane Glass Microfibre - PK100

SAR4322 PK100
EUR 282.15

Microscope Cover Glass (Borosilicate G

BG012C-10X100NO 1 unit
EUR 60.71
Description: Microscope Cover Glass (Borosilicate G

Glass Microfibre Filter Discs Gr GF/2 - 25mm - PK50

SLS4140 PK50
EUR 33.75

Glass Microfibre Filter Discs Gr GF/2 - 47mm - PK50

SLS4141 PK50
EUR 36.45

Glass Microfibre Filter Discs Gr GF/2 - 55mm - PK50

SLS4142 PK50
EUR 51.3

Glass Microfibre Filter Discs Gr GF/2 - 70mm - PK50

SLS4143 PK50
EUR 64.8

Glass Microfibre Filter Discs Gr GF/2 - 90mm - PK50

SLS4144 PK50
EUR 95.85

Glass Microfibre Filter Discs Gr GF/2 - 110mm - PK25

SLS4145 PK25
EUR 62.1

The optimized instrument parameters (translational pace = 0.150 in/s, revolution fee = 100 rpm, circulation fee = 0.6 ml/min) resulted in improved reproducibility of the drug load and related coating properties because the DCB. This research demonstrated the flexibility to automate the micropipette course of to acquire a balloon with optimum coating properties and drug tissue uptake.

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